DaVita Clinical Research Study Indicates Effectiveness of mRNA COVID-19 Vaccines in Dialysis Patients

Posted by: DaVita Clinical Research

Research supports vaccination as an important clinical strategy to help protect vulnerable patients from virus infection.

DENVERNov. 29, 2021 /PRNewswire/ — Dialysis patients who received mRNA COVID-19 vaccines had a lower risk of COVID-19 diagnosis post-vaccination and were less likely to be hospitalized or die following breakthrough infection than unvaccinated patients, according to a DaVita Clinical Research (DCR) study published online ahead of print by the Journal of the American Society of Nephrology.

“This is the first large study aimed at understanding the clinical effectiveness of COVID-19 vaccines in this highly vulnerable patient population,” said Dr. Steven Brunelli, MCSE, vice president for DCR. “Our observations provide reassurance that COVID-19 mRNA vaccination is an effective clinical strategy to help protect these patients from COVID-19 and from associated hospitalization and death.”

More than 500,000 Americans diagnosed with end stage kidney disease (ESKD) receive life-sustaining dialysis care. Despite being at high risk for COVID-19 due to underlying health conditions that compromise their immune systems, these patients were not represented in the Phase III clinical trials of BNT162b (Pfizer/BioNTech) and mRNA-1273 (Moderna) SARS-CoV-2 vaccines.

To assess COVID-19 vaccine effectiveness in this patient population, researchers evaluated electronic health records of 35,206 DaVita dialysis patients vaccinated with Pfizer/BioNTech or Moderna vaccines between Jan. 1 and Feb. 25, 2021. These patients were matched to unvaccinated controlled groups and followed over time to observe future COVID-19 infections and related clinical outcomes.

Researchers observed that the Pfizer/BioNTech and Moderna vaccines were 78% and 73% effective in preventing COVID-19 infections, respectively. The study indicated that vaccinated dialysis patients who experienced a breakthrough COVID-19 infection were also less likely to be hospitalized or die from COVID-19 as compared to unvaccinated patients diagnosed with COVID-19. In addition, among vaccinated dialysis patients, SARS-CoV-2 antibodies were detected in rates similar to those seen in the broader Phase III clinical trials.

Since the onset of the COVID-19 pandemic, DCR has conducted several studies to better understand how the novel coronavirus behaves in medically vulnerable patients with ESKD. Related research efforts also include two prospective studies in ESKD patients: one investigating the influence of prior infection/ naturally acquired antibodies on the future risk of infection, and a second one (ongoing) studying the genetic basis for susceptibility to more severe cases of COVID-19.

To learn more about DaVita Clinical Research, visit DaVitaClinicalResearch.com.