TQT Studies

Use our highly qualified clinical operations team that brings a wealth of knowledge and expertise in the area of critical Thorough QT/QTc (TQT) trials

Enrolled more than 2,000 subjects in either cross-over or parallel study designs

  • Including, but not limited to placebo, positive control, therapeutic and supratherapeutic drug development studies

Well established partnerships with key ECG core labratories

  • Designed to collect both Holter and manual ECGs

Unique insights grounded in leadership with extensive experience in drug development and clinical pharmacology which helps DCR

  • Identify and ameliorate known sources of QT variability
  • Take informed steps to ensure ECG recordings are obtained in a quiet and controlled environment

State-of-the-art facilities in Denver, Colorado and Minneapolis, Minnesota offer:

  • 24 channel Mortara™ Surveyor System for wireless ECG monitoring/telemetry
  • Hospital-based co-locations within St. Anthony’s Medical Center and Hennepin County Medical Center, both level 1 trauma facilities
  • Optimization for conduct of cardiac safety & FIM studies
  • 122 hospital/intensive care beds to accommodate large group sizes, minimize data variability, and shorten clinical conduct timelines
  • 24/7 Emergency Code Coverage via hospital critical care team

Strategically allied with BioTelemetry Research (fka CardioCore), enhancing DCR’s strength and knowledge to further support the needs of clients looking to optimize the design, conduct and reporting of cardiac safety studies

  • Offering a single contracting source and single point of contact throughout spectrum of cross-organizational services
  • Offering competitive bundle pricing and operational efficiency
  • Providing direct access to some of the world’s most experienced team of (tQT) scientists, unparalleled subject enrollment and bed capacity, integrated study management and accelerated data delivery
  • Offering utlization of BioTelemetry’s Cardioportal™ web-based system, allowing for real-time, on-line data access to view, download, print or email reports
  • Collectively working together, DCR and BioTelemetry have conducted 30 TQT studies as well as other non-TQT Phase 1 studies

Recently completed a 40 subject Multiple Ascending Dose (MAD) trial

  • Subjects confined for 16 days, on 24-hour telemetry for 15 days with over 100 ECG extractions per subject
  • Leveraged combined experience of DCR’s Denver team who have enrolled over 1,500+ subjects in cross-over or parallel study designs

Recent QTc study experience

  • Successful conduct of five intensive QT trials with subjects ranging from 16 to 40 and over 22,500 Holter extraction timepoints
  • Extensive Core Lab specific training of DCR team

QTc staff experience

  • DCR study teams have enrolled 1,800+ subjects in cross-over or parallel designed drug development studies